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Forskere opdager kræftfremkaldende stoffer i alkoholholdige drikkevarer

Forskere opdager kræftfremkaldende stoffer i alkoholholdige drikkevarer


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Forskere siger, at indtagelse af mere end 4 drikkevarer om dagen øger risikoen for kræft

Lidenskabelige vindrikkere er klar over de mange stoffer, der findes i deres vine. Ting som syrer, tanniner og resveratrol flyder rundt i hvert glas. En ny undersøgelse har fundet ud af, at der også kan findes kræftfremkaldende stoffer i disse vine, ifølge WineSpectator.com.

Undersøgelsen, udført af forskere ved Dresden University of Technology, fandt mere end spor af kræftfremkaldende stoffer i en prøve af kommercielle alkoholholdige drikkevarer, med dem fundet, herunder arsen, benzen, formaldehyd og bly. Forskerne fandt ud af, at ethanol, det kræftfremkaldende stof med den højeste koncentration i alkoholholdige drikkevarer, er tre og en halv gange større sandsynlighed for at forårsage kræft hos dem, der har fire eller flere drikkevarer om dagen end dem, der har færre, ifølge artiklen på WineSpectator. com.

Selvom undersøgelsen viste, at let til moderat alkoholforbrug bærer en lille risiko for kræft, sagde Dirk Lachenmeier, en epidemiolog og undersøgelsens hovedforfatter, at forbrugerne stadig skal gøres opmærksom på indholdet af deres drikkevarer. Fordi rødvin er kendt for sine sunde egenskaber, har Lachenmeier været nødt til at svare kritikere af hans fund ganske lidt.

Fra WineSpectator.com:

"Et argument mod forskernes pointe er, at nogle undersøgelser har fundet tegn på, at forbindelser i rødvin kan sænke brystkræftrisikoen. Lachenmeier indrømmede, at rødvin kan indeholde kræftforebyggende stoffer, men dette måles ikke i den nuværende undersøgelse. Han imødegår at disse konklusioner forbliver formodninger foreløbig. 'De fleste undersøgelser af sådanne forbindelser, som resveratrol, er baseret på in vitro-resultater, som ikke er anvendelige til kvantitative dosis-respons-analyser som udført i vores undersøgelse,' sagde han. "

- Wayne Stainrook, Glat


Forskere opdager, at menneskets krop producerede alkohol

(CNN) - Da en mand i North Carolina blev trukket tilbage mistænkt for at have kørt fuld, troede politiet ham ikke, da han sagde, at han ikke havde drukket alkohol.

Manden, i slutningen af ​​40'erne på det tidspunkt, nægtede at tage en alkometerstest og blev kørt til et hospital, hvor hans første alkoholindhold i blodet viste sig at være 0,2% - cirka 2,5 gange den lovlige grænse og svarende til at indtage 10 drikkevarer en time. På trods af at manden svor op og ned, at han ikke havde haft noget at drikke, troede lægerne ham heller ikke.

Men forskere ved Richmond University Medical Center i New York opdagede til sidst, at manden talte sandt. Han downer ikke øl eller cocktails - i stedet var der gær i tarmen, der sandsynligvis konverterede kulhydrater i den mad, han spiste til alkohol.

Med andre ord var hans krop ved at brygge øl.

Resultaterne blev rapporteret i en undersøgelse i BMJ Open Gastroenterology. Manden, hvis identitet ikke er blevet afsløret, havde en sjældent diagnosticeret medicinsk tilstand kaldet auto-brewery syndrom (ABS), også kendt som tarmgæringssyndrom.

Tarmgæringssyndrom opstår, når gær i mave -tarmkanalen får kroppen til at omdanne kulhydrater indtaget gennem mad til alkohol. Processen foregår typisk i den øvre GI -kanal, som omfatter maven og den første del af tyndtarmen.

"Disse patienter har nøjagtig de samme konsekvenser af alkoholisme: lugten, ånde, døsighed, gangændringer," siger Fahad Malik, undersøgelsens hovedforfatter og chef for internmedicin ved University of Alabama i Birmingham, til CNN. "De vil præsentere sig som en, der er beruset af alkohol, men den eneste forskel her er, at disse patienter kan behandles med svampedræbende medicin."

Forskere behandlede ham med svampedræbende medicin

Tingene var ikke det samme for manden, efter at han havde gennemført et kursus med antibiotika til behandling af en tommelfingerskade. Hans personlighed begyndte at ændre sig, skrev forskere i undersøgelsen, og han oplevede episoder med depression, 'hjernetåge', hukommelsestab og aggressiv adfærd, der var uden karakter for ham.

Tre år senere, efter hans formodede spirituskørsel, købte mandens tante en alkometer for at registrere hans alkoholindhold. Hun havde hørt om en lignende sag, der var blevet behandlet med succes af en læge i Ohio og overbevist hendes nevø om også at søge behandling der.

Hans grundlæggende laboratorietest viste sig at være normale. Men læger fandt to gærstammer i hans afføring: Saccharomyces cerevisiae, en gær, der almindeligvis bruges til ølbrygning, vinfremstilling og bagning, samt en anden svamp.

Manden blev behandlet med succes på Ohio-klinikken og fik besked på at holde sig til en streng kulhydratfri diæt sammen med nogle særlige kosttilskud. Men efter et par uger begyndte hans symptomer at blusse op igen. Denne gang syntes ingen behandling at fungere på trods af besøg hos mange læger.

På et tidspunkt blev manden så beruset, at han faldt og oplevede blødning i hans hjerne. Han blev taget til et neurokirurgisk center, hvor han spontant kom sig på 10 dage, sagde forskere.

"I denne institution varierede hans alkoholniveauer i blodet fra 50 til 400 mg/dL," skrev forskerne. "Også her nægtede lægerne at tro, at han ikke drak alkohol på trods af hans vedholdende benægtelse."

Endelig søgte manden hjælp fra en online supportgruppe og kom i kontakt med forskerne ved Richmond University Medical Center, der i undersøgelsen sagde, at de troede, at antibiotika, han tog for mange år siden, ændrede hans tarmmikrobiom og tillod svampe at vokse i hans mavetarmkanalen.

Forskerne brugte derefter svampedræbende behandlinger og probiotika til at hjælpe med at normalisere bakterierne i hans tarm, en behandling, som han har fortsat. Og bortset fra et tilbagefald, der opstod efter, at han bingede på pizza og sodavand uden at fortælle forskerne, ser det ud til at virke.

Og han kan spise pizza igen.

"Cirka 1,5 år senere forbliver han asymptomatisk og har genoptaget sin tidligere livsstil, herunder at spise en normal kost, mens han stadig kontrollerer sit ånde alkoholindhold sporadisk," skrev forfatterne i undersøgelsen.

Tilstanden diagnosticeres sjældent

Der har kun været få undersøgelser, der dokumenterer tilfælde af tarmgæringssyndrom, og tilstanden diagnosticeres sjældent, sagde Malik. Tidligere blev det endda betragtet som en myte.

Tarmgæringssyndrom blev beskrevet i 1912 som "kim -kulhydratfermentering" og blev undersøgt i 1930'erne og 1940'erne som en medvirkende faktor til vitaminmangel og irritabel tarmsyndrom. En gruppe på 20 til 30 tilfælde dukkede op i Japan i 1970'erne, og de første amerikanske tilfælde blev rapporteret cirka 10 år senere.

Der har været en håndfuld rapporterede tilfælde i de seneste år. En undersøgelse fra 2013 beskrev et tilfælde af en 61-årig mand, der i årevis syntes at være fuld hele tiden, før han fik diagnosen tarmgæringssyndrom. I 2015 fik en kvinde i delstaten New York en DUI afskediget efter at have fremlagt bevis for, at hun havde tilstanden.

Forfatterne til Richmond University Medical Center -undersøgelsen anbefaler, at læger undersøger tilstanden, især når en patient viser forhøjede alkoholniveauer i blodet på trods af at de har benægtet alkohol.

Tidlige tegn på tarmgæringssyndrom kan omfatte humørsvingninger, delirium og hjernetåge, skrev forskerne, selv før en patient begynder at udvise symptomer på alkoholindrusning.

Undersøgelsen siger, at der bør forskes mere i brugen af ​​probiotika som behandling af tilstanden.

"Dette er en tilstand, der kan behandles med kostændringer, passende antisvampeterapi og muligvis probiotika," skrev forskerne. "Brug af probiotika og fækal mikrobiotatransplantation kan overvejes til fremtidige undersøgelser."

The-CNN-Wire
™ & amp © 2019 Cable News Network, Inc., et WarnerMedia -selskab. Alle rettigheder forbeholdes.


Forskere opdager, at menneskets krop producerede alkohol

(CNN) - Da en mand i North Carolina blev trukket tilbage mistænkt for at have kørt fuld, troede politiet ham ikke, da han sagde, at han ikke havde drukket alkohol.

Manden, i slutningen af ​​40'erne på det tidspunkt, nægtede at tage en alkometerstest og blev kørt til et hospital, hvor hans første alkoholindhold i blodet viste sig at være 0,2% - cirka 2,5 gange den lovlige grænse og svarende til at indtage 10 drikkevarer en time. På trods af at manden svor op og ned, at han ikke havde haft noget at drikke, troede lægerne ham heller ikke.

Men forskere ved Richmond University Medical Center i New York opdagede til sidst, at manden talte sandt. Han downer ikke øl eller cocktails - i stedet var der gær i tarmen, der sandsynligvis konverterede kulhydrater i den mad, han spiste til alkohol.

Med andre ord var hans krop ved at brygge øl.

Resultaterne blev rapporteret i en undersøgelse i BMJ Open Gastroenterology. Manden, hvis identitet ikke er blevet afsløret, havde en sjældent diagnosticeret medicinsk tilstand kaldet auto-brewery syndrom (ABS), også kendt som tarmgæringssyndrom.

Tarmgæringssyndrom opstår, når gær i mave -tarmkanalen får kroppen til at omdanne kulhydrater indtaget gennem mad til alkohol. Processen foregår typisk i den øvre GI -kanal, som omfatter maven og den første del af tyndtarmen.

"Disse patienter har nøjagtig de samme konsekvenser af alkoholisme: lugten, åndedrættet, døsighed, gangændringer," siger Fahad Malik, hovedforfatter til undersøgelsen og chef for internmedicin ved University of Alabama i Birmingham, til CNN. "De vil præsentere sig som en, der er beruset af alkohol, men den eneste forskel her er, at disse patienter kan behandles med svampedræbende medicin."

Forskere behandlede ham med svampedræbende medicin

Ting var ikke det samme for manden, efter at han havde gennemført et antibiotikaforløb til behandling af en tommelfingerskade. Hans personlighed begyndte at ændre sig, skrev forskere i undersøgelsen, og han oplevede episoder med depression, 'hjernetåge', hukommelsestab og aggressiv adfærd, der var uden karakter for ham.

Tre år senere, efter hans formodede spirituskørsel, købte mandens tante en alkometer for at registrere hans alkoholindhold. Hun havde hørt om en lignende sag, der var blevet behandlet med succes af en læge i Ohio og overbevist hendes nevø om også at søge behandling der.

Hans grundlæggende laboratorietest viste sig at være normale. Men læger fandt to gærstammer i hans afføring: Saccharomyces cerevisiae, en gær, der almindeligvis bruges til ølbrygning, vinfremstilling og bagning, samt en anden svamp.

Manden blev behandlet med succes på Ohio-klinikken og fik besked på at holde sig til en streng kulhydratfri diæt sammen med nogle særlige kosttilskud. Men efter et par uger begyndte hans symptomer at blusse op igen. Denne gang syntes ingen behandling at fungere trods besøg hos mange læger.

På et tidspunkt blev manden så beruset, at han faldt og oplevede blødning i hans hjerne. Han blev taget til et neurokirurgisk center, hvor han spontant kom sig på 10 dage, sagde forskere.

"I denne institution varierede hans alkoholniveauer i blodet fra 50 til 400 mg/dL," skrev forskerne. "Også her nægtede lægerne at tro, at han ikke drak alkohol på trods af hans vedholdende benægtelse."

Endelig søgte manden hjælp fra en online supportgruppe og kom i kontakt med forskerne ved Richmond University Medical Center, der i undersøgelsen sagde, at de troede, at antibiotika, han tog for mange år siden, ændrede hans tarmmikrobiom og tillod svampe at vokse i hans mavetarmkanalen.

Forskerne brugte derefter svampedræbende behandlinger og probiotika til at hjælpe med at normalisere bakterierne i hans tarm, en behandling, som han har fortsat. Og bortset fra et tilbagefald, der opstod efter, at han bingede på pizza og sodavand uden at fortælle forskerne, ser det ud til at virke.

Og han kan spise pizza igen.

"Cirka 1,5 år senere forbliver han asymptomatisk og har genoptaget sin tidligere livsstil, herunder at spise en normal kost, mens han stadig kontrollerer sit ånde alkoholindhold sporadisk," skrev forfatterne i undersøgelsen.

Tilstanden diagnosticeres sjældent

Der har kun været få undersøgelser, der dokumenterer tilfælde af tarmgæringssyndrom, og tilstanden diagnosticeres sjældent, sagde Malik. Tidligere blev det endda betragtet som en myte.

Tarmgæringssyndrom blev beskrevet i 1912 som "kim -kulhydratfermentering" og blev undersøgt i 1930'erne og 1940'erne som en medvirkende faktor til vitaminmangel og irritabel tarmsyndrom. En gruppe på 20 til 30 tilfælde dukkede op i Japan i 1970'erne, og de første amerikanske tilfælde blev rapporteret cirka 10 år senere.

Der har været en håndfuld rapporterede tilfælde i de seneste år. En undersøgelse fra 2013 beskrev et tilfælde af en 61-årig mand, der i årevis syntes at være fuld hele tiden, før han fik diagnosen tarmgæringssyndrom. I 2015 fik en kvinde i delstaten New York en DUI afskediget efter at have fremlagt bevis for, at hun havde tilstanden.

Forfatterne af Richmond University Medical Center -undersøgelsen anbefaler, at læger undersøger tilstanden, især når en patient viser forhøjede alkoholniveauer i blodet på trods af at de har benægtet alkohol.

Tidlige tegn på tarmgæringssyndrom kan omfatte humørsvingninger, delirium og hjernetåge, skrev forskerne, selv før en patient begynder at udvise symptomer på alkoholindrusning.

Undersøgelsen siger, at der bør forskes mere i brugen af ​​probiotika som behandling af tilstanden.

"Dette er en tilstand, der kan behandles med kostændringer, passende antisvampeterapi og muligvis probiotika," skrev forskerne. "Brug af probiotika og fækal mikrobiotatransplantation kan overvejes til fremtidige undersøgelser."

The-CNN-Wire
™ & amp © 2019 Cable News Network, Inc., et WarnerMedia -selskab. Alle rettigheder forbeholdes.


Forskere opdager, at menneskets krop producerede alkohol

(CNN) - Da en mand i North Carolina blev trukket tilbage mistænkt for at have kørt fuld, troede politiet ham ikke, da han sagde, at han ikke havde drukket alkohol.

Manden, i slutningen af ​​40'erne på det tidspunkt, nægtede at tage en alkometerstest og blev kørt til et hospital, hvor hans første alkoholindhold i blodet viste sig at være 0,2% - cirka 2,5 gange den lovlige grænse og svarende til at indtage 10 drikkevarer en time. På trods af at manden svor op og ned, at han ikke havde haft noget at drikke, troede lægerne ham heller ikke.

Men forskere ved Richmond University Medical Center i New York opdagede til sidst, at manden talte sandt. Han downer ikke øl eller cocktails - i stedet var der gær i tarmen, der sandsynligvis konverterede kulhydrater i den mad, han spiste til alkohol.

Med andre ord var hans krop ved at brygge øl.

Resultaterne blev rapporteret i en undersøgelse i BMJ Open Gastroenterology. Manden, hvis identitet ikke er blevet afsløret, havde en sjældent diagnosticeret medicinsk tilstand kaldet auto-brewery syndrom (ABS), også kendt som tarmgæringssyndrom.

Tarmgæringssyndrom opstår, når gær i mave -tarmkanalen får kroppen til at omdanne kulhydrater indtaget gennem mad til alkohol. Processen foregår typisk i den øvre GI -kanal, som omfatter maven og den første del af tyndtarmen.

"Disse patienter har nøjagtig de samme konsekvenser af alkoholisme: lugten, åndedrættet, døsighed, gangændringer," siger Fahad Malik, hovedforfatter til undersøgelsen og chef for internmedicin ved University of Alabama i Birmingham, til CNN. "De vil præsentere sig som en, der er beruset af alkohol, men den eneste forskel her er, at disse patienter kan behandles med svampedræbende medicin."

Forskere behandlede ham med svampedræbende medicin

Ting var ikke det samme for manden, efter at han havde gennemført et antibiotikaforløb for at behandle en tommelfingerskade. Hans personlighed begyndte at ændre sig, skrev forskere i undersøgelsen, og han oplevede episoder med depression, 'hjernetåge', hukommelsestab og aggressiv adfærd, der var uden karakter for ham.

Tre år senere, efter hans formodede spirituskørsel, købte mandens tante en alkometer for at registrere hans alkoholindhold. Hun havde hørt om en lignende sag, der var blevet behandlet med succes af en læge i Ohio og overbevist hendes nevø om også at søge behandling der.

Hans grundlæggende laboratorietest viste sig at være normale. Men læger fandt to gærstammer i hans afføring: Saccharomyces cerevisiae, en gær, der almindeligvis bruges til ølbrygning, vinfremstilling og bagning, samt en anden svamp.

Manden blev behandlet med succes på Ohio-klinikken og fik besked på at holde sig til en streng kulhydratfri diæt sammen med nogle særlige kosttilskud. Men efter et par uger begyndte hans symptomer at blusse op igen. Denne gang syntes ingen behandling at fungere trods besøg hos mange læger.

På et tidspunkt blev manden så beruset, at han faldt og oplevede blødning i hans hjerne. Han blev taget til et neurokirurgisk center, hvor han spontant kom sig på 10 dage, sagde forskere.

"I denne institution varierede hans alkoholniveauer i blodet fra 50 til 400 mg/dL," skrev forskerne. "Også her nægtede lægerne at tro, at han ikke drak alkohol på trods af hans vedholdende benægtelse."

Endelig søgte manden hjælp fra en online supportgruppe og kom i kontakt med forskerne ved Richmond University Medical Center, der i undersøgelsen sagde, at de troede, at antibiotika, han tog for mange år siden, ændrede hans tarmmikrobiom og tillod svampe at vokse i hans mavetarmkanalen.

Forskerne brugte derefter svampedræbende behandlinger og probiotika til at hjælpe med at normalisere bakterierne i hans tarm, en behandling, som han har fortsat. Og bortset fra et tilbagefald, der opstod efter, at han spiste pizza og sodavand uden at fortælle forskerne, ser det ud til at virke.

Og han kan spise pizza igen.

"Cirka 1,5 år senere forbliver han asymptomatisk og har genoptaget sin tidligere livsstil, herunder at spise en normal kost, mens han stadig kontrollerer sit ånde alkoholindhold sporadisk," skrev forfatterne i undersøgelsen.

Tilstanden diagnosticeres sjældent

Der har kun været få undersøgelser, der dokumenterer tilfælde af tarmgæringssyndrom, og tilstanden diagnosticeres sjældent, sagde Malik. Tidligere blev det endda betragtet som en myte.

Gutfermenteringssyndrom blev beskrevet i 1912 som "kim -kulhydratfermentering", og blev undersøgt i 1930'erne og 1940'erne som en medvirkende faktor til vitaminmangel og irritabel tarmsyndrom. En gruppe på 20 til 30 tilfælde dukkede op i Japan i 1970'erne, og de første amerikanske tilfælde blev rapporteret cirka 10 år senere.

Der har været en håndfuld rapporterede tilfælde i de seneste år. En undersøgelse fra 2013 beskrev et tilfælde af en 61-årig mand, der i årevis syntes at være fuld hele tiden, før han fik diagnosen tarmgæringssyndrom. I 2015 fik en kvinde i delstaten New York en DUI afskediget efter at have fremlagt bevis for, at hun havde tilstanden.

Forfatterne af Richmond University Medical Center -undersøgelsen anbefaler, at læger undersøger tilstanden, især når en patient viser forhøjede alkoholniveauer i blodet på trods af at de har benægtet alkohol.

Tidlige tegn på tarmgæringssyndrom kan omfatte humørsvingninger, delirium og hjernetåge, skrev forskerne, selv før en patient begynder at udvise symptomer på alkoholindrusning.

Undersøgelsen siger, at der bør forskes mere i brugen af ​​probiotika som behandling af tilstanden.

"Dette er en tilstand, der kan behandles med kostændringer, passende antisvampeterapi og muligvis probiotika," skrev forskerne. "Brug af probiotika og fækal mikrobiotatransplantation kan overvejes til fremtidige undersøgelser."

The-CNN-Wire
™ & amp © 2019 Cable News Network, Inc., et WarnerMedia -selskab. Alle rettigheder forbeholdes.


Forskere opdager, at menneskets krop producerede alkohol

(CNN) - Da en mand i North Carolina blev trukket tilbage mistænkt for at have kørt fuld, troede politiet ham ikke, da han sagde, at han ikke havde drukket alkohol.

Manden, i slutningen af ​​40'erne på det tidspunkt, nægtede at tage en alkometerstest og blev kørt til et hospital, hvor hans første alkoholindhold i blodet viste sig at være 0,2% - cirka 2,5 gange den lovlige grænse og svarende til at indtage 10 drikkevarer en time. På trods af at manden svor op og ned, at han ikke havde haft noget at drikke, troede lægerne ham heller ikke.

Men forskere ved Richmond University Medical Center i New York opdagede til sidst, at manden talte sandt. Han downer ikke øl eller cocktails - i stedet var der gær i tarmen, der sandsynligvis konverterede kulhydrater i den mad, han spiste til alkohol.

Med andre ord var hans krop ved at brygge øl.

Resultaterne blev rapporteret i en undersøgelse i BMJ Open Gastroenterology. Manden, hvis identitet ikke er blevet afsløret, havde en sjældent diagnosticeret medicinsk tilstand kaldet auto-brewery syndrom (ABS), også kendt som tarmgæringssyndrom.

Tarmgæringssyndrom opstår, når gær i mave -tarmkanalen får kroppen til at omdanne kulhydrater indtaget gennem mad til alkohol. Processen foregår typisk i den øvre GI -kanal, som omfatter maven og den første del af tyndtarmen.

"Disse patienter har nøjagtig de samme konsekvenser af alkoholisme: lugten, ånde, døsighed, gangændringer," siger Fahad Malik, undersøgelsens hovedforfatter og chef for internmedicin ved University of Alabama i Birmingham, til CNN. "De vil præsentere sig som en, der er beruset af alkohol, men den eneste forskel her er, at disse patienter kan behandles med svampedræbende medicin."

Forskere behandlede ham med svampedræbende medicin

Ting var ikke det samme for manden, efter at han havde gennemført et antibiotikaforløb til behandling af en tommelfingerskade. Hans personlighed begyndte at ændre sig, skrev forskere i undersøgelsen, og han oplevede episoder med depression, 'hjernetåge', hukommelsestab og aggressiv adfærd, der var uden karakter for ham.

Tre år senere, efter hans formodede spirituskørsel, købte mandens tante en alkometer for at registrere hans alkoholindhold. Hun havde hørt om en lignende sag, der var blevet behandlet med succes af en læge i Ohio og overbevist hendes nevø om også at søge behandling der.

Hans grundlæggende laboratorietest viste sig at være normale. Men læger fandt to gærstammer i hans afføring: Saccharomyces cerevisiae, en gær, der almindeligvis bruges til ølbrygning, vinfremstilling og bagning, samt en anden svamp.

Manden blev behandlet med succes på Ohio-klinikken og fik besked på at holde sig til en streng kulhydratfri diæt sammen med nogle særlige kosttilskud. Men efter et par uger begyndte hans symptomer at blusse op igen. Denne gang syntes ingen behandling at fungere trods besøg hos mange læger.

På et tidspunkt blev manden så beruset, at han faldt og oplevede blødning i hans hjerne. Han blev taget til et neurokirurgisk center, hvor han spontant kom sig på 10 dage, sagde forskere.

"I denne institution varierede hans alkoholniveauer i blodet fra 50 til 400 mg/dL," skrev forskerne. "Også her nægtede lægerne at tro, at han ikke drak alkohol på trods af hans vedholdende benægtelse."

Endelig søgte manden hjælp fra en online supportgruppe og kom i kontakt med forskerne ved Richmond University Medical Center, der i undersøgelsen sagde, at de troede, at antibiotika, han tog for mange år siden, ændrede hans tarmmikrobiom og tillod svampe at vokse i hans mavetarmkanalen.

Forskerne brugte derefter svampedræbende behandlinger og probiotika til at hjælpe med at normalisere bakterierne i hans tarm, en behandling, som han har fortsat. Og bortset fra et tilbagefald, der opstod efter, at han spiste pizza og sodavand uden at fortælle forskerne, ser det ud til at virke.

Og han kan spise pizza igen.

"Cirka 1,5 år senere forbliver han asymptomatisk og har genoptaget sin tidligere livsstil, herunder at spise en normal kost, mens han stadig kontrollerer sit ånde alkoholindhold sporadisk," skrev forfatterne i undersøgelsen.

Tilstanden diagnosticeres sjældent

Der har kun været få undersøgelser, der dokumenterer tilfælde af tarmgæringssyndrom, og tilstanden diagnosticeres sjældent, sagde Malik. Tidligere blev det endda betragtet som en myte.

Tarmgæringssyndrom blev beskrevet i 1912 som "kim -kulhydratfermentering" og blev undersøgt i 1930'erne og 1940'erne som en medvirkende faktor til vitaminmangel og irritabel tarmsyndrom. En gruppe på 20 til 30 tilfælde dukkede op i Japan i 1970'erne, og de første amerikanske tilfælde blev rapporteret cirka 10 år senere.

Der har været en håndfuld rapporterede tilfælde i de seneste år. En undersøgelse fra 2013 beskrev et tilfælde af en 61-årig mand, der i årevis syntes at være fuld hele tiden, før han fik diagnosen tarmgæringssyndrom. I 2015 fik en kvinde i delstaten New York en DUI afskediget efter at have fremlagt bevis for, at hun havde tilstanden.

Forfatterne til Richmond University Medical Center -undersøgelsen anbefaler, at læger undersøger tilstanden, især når en patient viser forhøjede alkoholniveauer i blodet på trods af at de har benægtet alkohol.

Tidlige tegn på tarmgæringssyndrom kan omfatte humørsvingninger, delirium og hjernetåge, skrev forskerne, selv før en patient begynder at udvise symptomer på alkoholindrusning.

Undersøgelsen siger, at der bør forskes mere i brugen af ​​probiotika som behandling af tilstanden.

"Dette er en tilstand, der kan behandles med kostændringer, passende antisvampeterapi og muligvis probiotika," skrev forskerne. "Brug af probiotika og fækal mikrobiotatransplantation kan overvejes til fremtidige undersøgelser."

The-CNN-Wire
™ & amp © 2019 Cable News Network, Inc., et WarnerMedia -selskab. Alle rettigheder forbeholdes.


Forskere opdager, at menneskets krop producerede alkohol

(CNN) - Da en mand i North Carolina blev trukket tilbage mistænkt for at have kørt fuld, troede politiet ham ikke, da han sagde, at han ikke havde drukket alkohol.

Manden, i slutningen af ​​40'erne på det tidspunkt, nægtede at tage en alkometerstest og blev kørt til et hospital, hvor hans første alkoholindhold i blodet viste sig at være 0,2% - cirka 2,5 gange den lovlige grænse og svarende til at indtage 10 drikkevarer en time. På trods af at manden svor op og ned, at han ikke havde haft noget at drikke, troede lægerne ham heller ikke.

Men forskere ved Richmond University Medical Center i New York opdagede til sidst, at manden talte sandt. Han downer ikke øl eller cocktails - i stedet var der gær i tarmen, der sandsynligvis konverterede kulhydrater i den mad, han spiste til alkohol.

Med andre ord var hans krop ved at brygge øl.

Resultaterne blev rapporteret i en undersøgelse i BMJ Open Gastroenterology. Manden, hvis identitet ikke er blevet afsløret, havde en sjældent diagnosticeret medicinsk tilstand kaldet auto-brewery syndrom (ABS), også kendt som tarmgæringssyndrom.

Tarmgæringssyndrom opstår, når gær i mave -tarmkanalen får kroppen til at omdanne kulhydrater indtaget gennem mad til alkohol. Processen foregår typisk i den øvre GI -kanal, som omfatter maven og den første del af tyndtarmen.

"Disse patienter har nøjagtig de samme konsekvenser af alkoholisme: lugten, ånde, døsighed, gangændringer," siger Fahad Malik, undersøgelsens hovedforfatter og chef for internmedicin ved University of Alabama i Birmingham, til CNN. "De vil præsentere sig som en, der er beruset af alkohol, men den eneste forskel her er, at disse patienter kan behandles med svampedræbende medicin."

Forskere behandlede ham med svampedræbende medicin

Ting var ikke det samme for manden, efter at han havde gennemført et antibiotikaforløb for at behandle en tommelfingerskade. Hans personlighed begyndte at ændre sig, skrev forskere i undersøgelsen, og han oplevede episoder med depression, 'hjernetåge', hukommelsestab og aggressiv adfærd, der var uden karakter for ham.

Tre år senere, efter hans formodede spirituskørsel, købte mandens tante en alkometer for at registrere hans alkoholindhold. Hun havde hørt om en lignende sag, der var blevet behandlet med succes af en læge i Ohio og overbevist hendes nevø om også at søge behandling der.

Hans grundlæggende laboratorietest viste sig at være normale. Men læger fandt to gærstammer i hans afføring: Saccharomyces cerevisiae, en gær, der almindeligvis bruges til ølbrygning, vinfremstilling og bagning, samt en anden svamp.

Manden blev behandlet med succes på Ohio-klinikken og fik besked på at holde sig til en streng kulhydratfri diæt sammen med nogle særlige kosttilskud. Men efter et par uger begyndte hans symptomer at blusse op igen. Denne gang syntes ingen behandling at fungere trods besøg hos mange læger.

På et tidspunkt blev manden så beruset, at han faldt og oplevede blødning i hans hjerne. Han blev taget til et neurokirurgisk center, hvor han spontant kom sig på 10 dage, sagde forskere.

"I denne institution varierede hans alkoholniveauer i blodet fra 50 til 400 mg/dL," skrev forskerne. "Også her nægtede lægerne at tro, at han ikke drak alkohol på trods af hans vedholdende benægtelse."

Endelig søgte manden hjælp fra en online supportgruppe og kom i kontakt med forskerne ved Richmond University Medical Center, der i undersøgelsen sagde, at de troede, at antibiotika, han tog for mange år siden, ændrede hans tarmmikrobiom og tillod svampe at vokse i hans mavetarmkanalen.

Forskerne brugte derefter svampedræbende behandlinger og probiotika til at hjælpe med at normalisere bakterierne i hans tarm, en behandling, som han har fortsat. Og bortset fra et tilbagefald, der opstod efter, at han spiste pizza og sodavand uden at fortælle forskerne, ser det ud til at virke.

Og han kan spise pizza igen.

"Cirka 1,5 år senere forbliver han asymptomatisk og har genoptaget sin tidligere livsstil, herunder at spise en normal kost, mens han stadig kontrollerer sit ånde alkoholindhold sporadisk," skrev forfatterne i undersøgelsen.

Tilstanden diagnosticeres sjældent

Der har kun været få undersøgelser, der dokumenterer tilfælde af tarmgæringssyndrom, og tilstanden diagnosticeres sjældent, sagde Malik. Tidligere blev det endda betragtet som en myte.

Gutfermenteringssyndrom blev beskrevet i 1912 som "kim -kulhydratfermentering", og blev undersøgt i 1930'erne og 1940'erne som en medvirkende faktor til vitaminmangel og irritabel tarmsyndrom. En gruppe på 20 til 30 tilfælde dukkede op i Japan i 1970'erne, og de første amerikanske tilfælde blev rapporteret cirka 10 år senere.

Der har været en håndfuld rapporterede tilfælde i de seneste år. En undersøgelse fra 2013 beskrev et tilfælde af en 61-årig mand, der i årevis syntes at være fuld hele tiden, før han fik diagnosen tarmgæringssyndrom. I 2015 fik en kvinde i delstaten New York en DUI afskediget efter at have fremlagt bevis for, at hun havde tilstanden.

Forfatterne til Richmond University Medical Center -undersøgelsen anbefaler, at læger undersøger tilstanden, især når en patient viser forhøjede alkoholniveauer i blodet på trods af at de har benægtet alkohol.

Tidlige tegn på tarmgæringssyndrom kan omfatte humørsvingninger, delirium og hjernetåge, skrev forskerne, selv før en patient begynder at udvise symptomer på alkoholindrusning.

Undersøgelsen siger, at der bør forskes mere i brugen af ​​probiotika som behandling af tilstanden.

"This is a condition that is treatable with dietary modifications, appropriate antifungal therapy, and possibly probiotics," the researchers wrote. "The use of probiotics and faecal microbiota transplantation could be considered for future studies."

The-CNN-Wire
™ & © 2019 Cable News Network, Inc., a WarnerMedia Company. Alle rettigheder forbeholdes.


Researchers discover that man's body was producing alcohol

(CNN) -- When a man in North Carolina was pulled over on suspicion of driving drunk, police didn't believe him when he said he hadn't had any alcohol.

The man, in his late 40's at the time, refused to take a breathalyzer test and was taken to a hospital, where his initial blood alcohol level was found to be 0.2% — about 2.5 times the legal limit and the equivalent of consuming 10 drinks an hour. Despite the man swearing up and down that he hadn't had anything to drink, doctors didn't believe him either.

But researchers at the Richmond University Medical Center in New York eventually discovered that the man was telling the truth. He wasn't downing beers or cocktails — instead, there was yeast in his gut that was likely converting carbohydrates in the food he ate to alcohol.

In other words, his body was brewing beer.

The findings were reported in a study in BMJ Open Gastroenterology. The man, whose identity has not been revealed, had a rarely diagnosed medical condition called auto-brewery syndrome (ABS), also known as gut fermentation syndrome.

Gut fermentation syndrome occurs when yeast in the gastrointestinal tract causes the body to convert carbohydrates ingested through food into alcohol. The process typically takes place in the upper GI tract, which includes the stomach and the first part of the small intestine.

"These patients have the exact same implications of alcoholism: the smell, the breath, drowsiness, gait changes," Fahad Malik, the study's lead author and the chief internal medicine resident at the University of Alabama at Birmingham, told CNN. "They will present as someone who's intoxicated by alcohol, but the only difference here is that these patients can be treated by antifungal medications."

Researchers treated him with antifungal medications

Things weren't the same for the man after he completed a course of antibiotics to treat a thumb injury. His personality started to change, researchers wrote in the study, and he experienced episodes of depression, 'brain fog,' memory loss and aggressive behavior that was out of character for him.

Three years later, after his suspected drunk driving arrest, the man's aunt bought a breathalyzer to record his alcohol levels. She had heard about a similar case that had been successfully treated by a doctor in Ohio and convinced her nephew to seek treatment there too.

His basic lab tests turned out normal. But doctors found two strains of yeast in his stool: Saccharomyces cerevisiae, a yeast commonly used in beer brewing, winemaking and baking, as well as another fungus.

The man was successfully treated at the Ohio clinic and told to stick to a strict carbohydrate-free diet along with some special supplements. But after a few weeks, his symptoms started to flare up again. This time, no treatment seemed to work despite visits to numerous medical professionals.

At one point, the man became so inebriated that he fell and experienced bleeding in his brain. He was taken to a neurosurgical center where he spontaneously recovered in 10 days, researchers said.

"In this institution, his blood alcohol levels ranged from 50 to 400 mg/dL," the researchers wrote. "Here too, the medical staff refused to believe that he did not drink alcohol despite his persistent denials."

Finally, the man sought help from an online support group and got in touch with the researchers at the Richmond University Medical Center, who said in the study that they believed the antibiotics he took years ago altered his gut microbiome and allowed fungi to grow in his gastrointestinal tract.

The researchers then used antifungal therapies and probiotics to help normalize the bacteria in his gut, a treatment that he has continued. And aside from one relapse that occurred after he binged on pizza and soda without telling the researchers, it seems to be working.

And he can eat pizza again.

"Approximately 1.5 years later, he remains asymptomatic and has resumed his previous lifestyle, including eating a normal diet while still checking his breath alcohol levels sporadically," the authors wrote in the study.

The condition is rarely diagnosed

There have only been a few studies documenting cases of gut fermentation syndrome and the condition is rarely diagnosed, Malik said. In the past, it's even been regarded as a myth.

Gut fermentation syndrome was described in 1912 as "germ carbohydrate fermentation," and was studied in the 1930s and 1940s as a contributing factor to vitamin deficiencies and irritable bowel syndrome. A group of 20 to 30 cases popped up in Japan in the 1970s and the first US cases were reported about 10 years later.

There have been a handful of reported cases in recent years. A 2013 study described a case of a 61-year-old man who for years seemed to be drunk all the time before he was diagnosed with gut fermentation syndrome. In 2015, a woman in upstate New York had a DUI dismissed after presenting evidence that she had the condition.

The authors of the Richmond University Medical Center study recommend that doctors investigate for the condition especially when a patient shows elevated blood alcohol levels despite denying that they consumed alcohol.

Early signs of gut fermentation syndrome can include mood changes, delirium and brain fog, the researchers wrote, even before a patient starts exhibiting symptoms of alcohol inebriation.

The study says more research should be done on the use of probiotics as a treatment for the condition.

"This is a condition that is treatable with dietary modifications, appropriate antifungal therapy, and possibly probiotics," the researchers wrote. "The use of probiotics and faecal microbiota transplantation could be considered for future studies."

The-CNN-Wire
™ & © 2019 Cable News Network, Inc., a WarnerMedia Company. Alle rettigheder forbeholdes.


Researchers discover that man's body was producing alcohol

(CNN) -- When a man in North Carolina was pulled over on suspicion of driving drunk, police didn't believe him when he said he hadn't had any alcohol.

The man, in his late 40's at the time, refused to take a breathalyzer test and was taken to a hospital, where his initial blood alcohol level was found to be 0.2% — about 2.5 times the legal limit and the equivalent of consuming 10 drinks an hour. Despite the man swearing up and down that he hadn't had anything to drink, doctors didn't believe him either.

But researchers at the Richmond University Medical Center in New York eventually discovered that the man was telling the truth. He wasn't downing beers or cocktails — instead, there was yeast in his gut that was likely converting carbohydrates in the food he ate to alcohol.

In other words, his body was brewing beer.

The findings were reported in a study in BMJ Open Gastroenterology. The man, whose identity has not been revealed, had a rarely diagnosed medical condition called auto-brewery syndrome (ABS), also known as gut fermentation syndrome.

Gut fermentation syndrome occurs when yeast in the gastrointestinal tract causes the body to convert carbohydrates ingested through food into alcohol. The process typically takes place in the upper GI tract, which includes the stomach and the first part of the small intestine.

"These patients have the exact same implications of alcoholism: the smell, the breath, drowsiness, gait changes," Fahad Malik, the study's lead author and the chief internal medicine resident at the University of Alabama at Birmingham, told CNN. "They will present as someone who's intoxicated by alcohol, but the only difference here is that these patients can be treated by antifungal medications."

Researchers treated him with antifungal medications

Things weren't the same for the man after he completed a course of antibiotics to treat a thumb injury. His personality started to change, researchers wrote in the study, and he experienced episodes of depression, 'brain fog,' memory loss and aggressive behavior that was out of character for him.

Three years later, after his suspected drunk driving arrest, the man's aunt bought a breathalyzer to record his alcohol levels. She had heard about a similar case that had been successfully treated by a doctor in Ohio and convinced her nephew to seek treatment there too.

His basic lab tests turned out normal. But doctors found two strains of yeast in his stool: Saccharomyces cerevisiae, a yeast commonly used in beer brewing, winemaking and baking, as well as another fungus.

The man was successfully treated at the Ohio clinic and told to stick to a strict carbohydrate-free diet along with some special supplements. But after a few weeks, his symptoms started to flare up again. This time, no treatment seemed to work despite visits to numerous medical professionals.

At one point, the man became so inebriated that he fell and experienced bleeding in his brain. He was taken to a neurosurgical center where he spontaneously recovered in 10 days, researchers said.

"In this institution, his blood alcohol levels ranged from 50 to 400 mg/dL," the researchers wrote. "Here too, the medical staff refused to believe that he did not drink alcohol despite his persistent denials."

Finally, the man sought help from an online support group and got in touch with the researchers at the Richmond University Medical Center, who said in the study that they believed the antibiotics he took years ago altered his gut microbiome and allowed fungi to grow in his gastrointestinal tract.

The researchers then used antifungal therapies and probiotics to help normalize the bacteria in his gut, a treatment that he has continued. And aside from one relapse that occurred after he binged on pizza and soda without telling the researchers, it seems to be working.

And he can eat pizza again.

"Approximately 1.5 years later, he remains asymptomatic and has resumed his previous lifestyle, including eating a normal diet while still checking his breath alcohol levels sporadically," the authors wrote in the study.

The condition is rarely diagnosed

There have only been a few studies documenting cases of gut fermentation syndrome and the condition is rarely diagnosed, Malik said. In the past, it's even been regarded as a myth.

Gut fermentation syndrome was described in 1912 as "germ carbohydrate fermentation," and was studied in the 1930s and 1940s as a contributing factor to vitamin deficiencies and irritable bowel syndrome. A group of 20 to 30 cases popped up in Japan in the 1970s and the first US cases were reported about 10 years later.

There have been a handful of reported cases in recent years. A 2013 study described a case of a 61-year-old man who for years seemed to be drunk all the time before he was diagnosed with gut fermentation syndrome. In 2015, a woman in upstate New York had a DUI dismissed after presenting evidence that she had the condition.

The authors of the Richmond University Medical Center study recommend that doctors investigate for the condition especially when a patient shows elevated blood alcohol levels despite denying that they consumed alcohol.

Early signs of gut fermentation syndrome can include mood changes, delirium and brain fog, the researchers wrote, even before a patient starts exhibiting symptoms of alcohol inebriation.

The study says more research should be done on the use of probiotics as a treatment for the condition.

"This is a condition that is treatable with dietary modifications, appropriate antifungal therapy, and possibly probiotics," the researchers wrote. "The use of probiotics and faecal microbiota transplantation could be considered for future studies."

The-CNN-Wire
™ & © 2019 Cable News Network, Inc., a WarnerMedia Company. Alle rettigheder forbeholdes.


Researchers discover that man's body was producing alcohol

(CNN) -- When a man in North Carolina was pulled over on suspicion of driving drunk, police didn't believe him when he said he hadn't had any alcohol.

The man, in his late 40's at the time, refused to take a breathalyzer test and was taken to a hospital, where his initial blood alcohol level was found to be 0.2% — about 2.5 times the legal limit and the equivalent of consuming 10 drinks an hour. Despite the man swearing up and down that he hadn't had anything to drink, doctors didn't believe him either.

But researchers at the Richmond University Medical Center in New York eventually discovered that the man was telling the truth. He wasn't downing beers or cocktails — instead, there was yeast in his gut that was likely converting carbohydrates in the food he ate to alcohol.

In other words, his body was brewing beer.

The findings were reported in a study in BMJ Open Gastroenterology. The man, whose identity has not been revealed, had a rarely diagnosed medical condition called auto-brewery syndrome (ABS), also known as gut fermentation syndrome.

Gut fermentation syndrome occurs when yeast in the gastrointestinal tract causes the body to convert carbohydrates ingested through food into alcohol. The process typically takes place in the upper GI tract, which includes the stomach and the first part of the small intestine.

"These patients have the exact same implications of alcoholism: the smell, the breath, drowsiness, gait changes," Fahad Malik, the study's lead author and the chief internal medicine resident at the University of Alabama at Birmingham, told CNN. "They will present as someone who's intoxicated by alcohol, but the only difference here is that these patients can be treated by antifungal medications."

Researchers treated him with antifungal medications

Things weren't the same for the man after he completed a course of antibiotics to treat a thumb injury. His personality started to change, researchers wrote in the study, and he experienced episodes of depression, 'brain fog,' memory loss and aggressive behavior that was out of character for him.

Three years later, after his suspected drunk driving arrest, the man's aunt bought a breathalyzer to record his alcohol levels. She had heard about a similar case that had been successfully treated by a doctor in Ohio and convinced her nephew to seek treatment there too.

His basic lab tests turned out normal. But doctors found two strains of yeast in his stool: Saccharomyces cerevisiae, a yeast commonly used in beer brewing, winemaking and baking, as well as another fungus.

The man was successfully treated at the Ohio clinic and told to stick to a strict carbohydrate-free diet along with some special supplements. But after a few weeks, his symptoms started to flare up again. This time, no treatment seemed to work despite visits to numerous medical professionals.

At one point, the man became so inebriated that he fell and experienced bleeding in his brain. He was taken to a neurosurgical center where he spontaneously recovered in 10 days, researchers said.

"In this institution, his blood alcohol levels ranged from 50 to 400 mg/dL," the researchers wrote. "Here too, the medical staff refused to believe that he did not drink alcohol despite his persistent denials."

Finally, the man sought help from an online support group and got in touch with the researchers at the Richmond University Medical Center, who said in the study that they believed the antibiotics he took years ago altered his gut microbiome and allowed fungi to grow in his gastrointestinal tract.

The researchers then used antifungal therapies and probiotics to help normalize the bacteria in his gut, a treatment that he has continued. And aside from one relapse that occurred after he binged on pizza and soda without telling the researchers, it seems to be working.

And he can eat pizza again.

"Approximately 1.5 years later, he remains asymptomatic and has resumed his previous lifestyle, including eating a normal diet while still checking his breath alcohol levels sporadically," the authors wrote in the study.

The condition is rarely diagnosed

There have only been a few studies documenting cases of gut fermentation syndrome and the condition is rarely diagnosed, Malik said. In the past, it's even been regarded as a myth.

Gut fermentation syndrome was described in 1912 as "germ carbohydrate fermentation," and was studied in the 1930s and 1940s as a contributing factor to vitamin deficiencies and irritable bowel syndrome. A group of 20 to 30 cases popped up in Japan in the 1970s and the first US cases were reported about 10 years later.

There have been a handful of reported cases in recent years. A 2013 study described a case of a 61-year-old man who for years seemed to be drunk all the time before he was diagnosed with gut fermentation syndrome. In 2015, a woman in upstate New York had a DUI dismissed after presenting evidence that she had the condition.

The authors of the Richmond University Medical Center study recommend that doctors investigate for the condition especially when a patient shows elevated blood alcohol levels despite denying that they consumed alcohol.

Early signs of gut fermentation syndrome can include mood changes, delirium and brain fog, the researchers wrote, even before a patient starts exhibiting symptoms of alcohol inebriation.

The study says more research should be done on the use of probiotics as a treatment for the condition.

"This is a condition that is treatable with dietary modifications, appropriate antifungal therapy, and possibly probiotics," the researchers wrote. "The use of probiotics and faecal microbiota transplantation could be considered for future studies."

The-CNN-Wire
™ & © 2019 Cable News Network, Inc., a WarnerMedia Company. Alle rettigheder forbeholdes.


Researchers discover that man's body was producing alcohol

(CNN) -- When a man in North Carolina was pulled over on suspicion of driving drunk, police didn't believe him when he said he hadn't had any alcohol.

The man, in his late 40's at the time, refused to take a breathalyzer test and was taken to a hospital, where his initial blood alcohol level was found to be 0.2% — about 2.5 times the legal limit and the equivalent of consuming 10 drinks an hour. Despite the man swearing up and down that he hadn't had anything to drink, doctors didn't believe him either.

But researchers at the Richmond University Medical Center in New York eventually discovered that the man was telling the truth. He wasn't downing beers or cocktails — instead, there was yeast in his gut that was likely converting carbohydrates in the food he ate to alcohol.

In other words, his body was brewing beer.

The findings were reported in a study in BMJ Open Gastroenterology. The man, whose identity has not been revealed, had a rarely diagnosed medical condition called auto-brewery syndrome (ABS), also known as gut fermentation syndrome.

Gut fermentation syndrome occurs when yeast in the gastrointestinal tract causes the body to convert carbohydrates ingested through food into alcohol. The process typically takes place in the upper GI tract, which includes the stomach and the first part of the small intestine.

"These patients have the exact same implications of alcoholism: the smell, the breath, drowsiness, gait changes," Fahad Malik, the study's lead author and the chief internal medicine resident at the University of Alabama at Birmingham, told CNN. "They will present as someone who's intoxicated by alcohol, but the only difference here is that these patients can be treated by antifungal medications."

Researchers treated him with antifungal medications

Things weren't the same for the man after he completed a course of antibiotics to treat a thumb injury. His personality started to change, researchers wrote in the study, and he experienced episodes of depression, 'brain fog,' memory loss and aggressive behavior that was out of character for him.

Three years later, after his suspected drunk driving arrest, the man's aunt bought a breathalyzer to record his alcohol levels. She had heard about a similar case that had been successfully treated by a doctor in Ohio and convinced her nephew to seek treatment there too.

His basic lab tests turned out normal. But doctors found two strains of yeast in his stool: Saccharomyces cerevisiae, a yeast commonly used in beer brewing, winemaking and baking, as well as another fungus.

The man was successfully treated at the Ohio clinic and told to stick to a strict carbohydrate-free diet along with some special supplements. But after a few weeks, his symptoms started to flare up again. This time, no treatment seemed to work despite visits to numerous medical professionals.

At one point, the man became so inebriated that he fell and experienced bleeding in his brain. He was taken to a neurosurgical center where he spontaneously recovered in 10 days, researchers said.

"In this institution, his blood alcohol levels ranged from 50 to 400 mg/dL," the researchers wrote. "Here too, the medical staff refused to believe that he did not drink alcohol despite his persistent denials."

Finally, the man sought help from an online support group and got in touch with the researchers at the Richmond University Medical Center, who said in the study that they believed the antibiotics he took years ago altered his gut microbiome and allowed fungi to grow in his gastrointestinal tract.

The researchers then used antifungal therapies and probiotics to help normalize the bacteria in his gut, a treatment that he has continued. And aside from one relapse that occurred after he binged on pizza and soda without telling the researchers, it seems to be working.

And he can eat pizza again.

"Approximately 1.5 years later, he remains asymptomatic and has resumed his previous lifestyle, including eating a normal diet while still checking his breath alcohol levels sporadically," the authors wrote in the study.

The condition is rarely diagnosed

There have only been a few studies documenting cases of gut fermentation syndrome and the condition is rarely diagnosed, Malik said. In the past, it's even been regarded as a myth.

Gut fermentation syndrome was described in 1912 as "germ carbohydrate fermentation," and was studied in the 1930s and 1940s as a contributing factor to vitamin deficiencies and irritable bowel syndrome. A group of 20 to 30 cases popped up in Japan in the 1970s and the first US cases were reported about 10 years later.

There have been a handful of reported cases in recent years. A 2013 study described a case of a 61-year-old man who for years seemed to be drunk all the time before he was diagnosed with gut fermentation syndrome. In 2015, a woman in upstate New York had a DUI dismissed after presenting evidence that she had the condition.

The authors of the Richmond University Medical Center study recommend that doctors investigate for the condition especially when a patient shows elevated blood alcohol levels despite denying that they consumed alcohol.

Early signs of gut fermentation syndrome can include mood changes, delirium and brain fog, the researchers wrote, even before a patient starts exhibiting symptoms of alcohol inebriation.

The study says more research should be done on the use of probiotics as a treatment for the condition.

"This is a condition that is treatable with dietary modifications, appropriate antifungal therapy, and possibly probiotics," the researchers wrote. "The use of probiotics and faecal microbiota transplantation could be considered for future studies."

The-CNN-Wire
™ & © 2019 Cable News Network, Inc., a WarnerMedia Company. Alle rettigheder forbeholdes.


Researchers discover that man's body was producing alcohol

(CNN) -- When a man in North Carolina was pulled over on suspicion of driving drunk, police didn't believe him when he said he hadn't had any alcohol.

The man, in his late 40's at the time, refused to take a breathalyzer test and was taken to a hospital, where his initial blood alcohol level was found to be 0.2% — about 2.5 times the legal limit and the equivalent of consuming 10 drinks an hour. Despite the man swearing up and down that he hadn't had anything to drink, doctors didn't believe him either.

But researchers at the Richmond University Medical Center in New York eventually discovered that the man was telling the truth. He wasn't downing beers or cocktails — instead, there was yeast in his gut that was likely converting carbohydrates in the food he ate to alcohol.

In other words, his body was brewing beer.

The findings were reported in a study in BMJ Open Gastroenterology. The man, whose identity has not been revealed, had a rarely diagnosed medical condition called auto-brewery syndrome (ABS), also known as gut fermentation syndrome.

Gut fermentation syndrome occurs when yeast in the gastrointestinal tract causes the body to convert carbohydrates ingested through food into alcohol. The process typically takes place in the upper GI tract, which includes the stomach and the first part of the small intestine.

"These patients have the exact same implications of alcoholism: the smell, the breath, drowsiness, gait changes," Fahad Malik, the study's lead author and the chief internal medicine resident at the University of Alabama at Birmingham, told CNN. "They will present as someone who's intoxicated by alcohol, but the only difference here is that these patients can be treated by antifungal medications."

Researchers treated him with antifungal medications

Things weren't the same for the man after he completed a course of antibiotics to treat a thumb injury. His personality started to change, researchers wrote in the study, and he experienced episodes of depression, 'brain fog,' memory loss and aggressive behavior that was out of character for him.

Three years later, after his suspected drunk driving arrest, the man's aunt bought a breathalyzer to record his alcohol levels. She had heard about a similar case that had been successfully treated by a doctor in Ohio and convinced her nephew to seek treatment there too.

His basic lab tests turned out normal. But doctors found two strains of yeast in his stool: Saccharomyces cerevisiae, a yeast commonly used in beer brewing, winemaking and baking, as well as another fungus.

The man was successfully treated at the Ohio clinic and told to stick to a strict carbohydrate-free diet along with some special supplements. But after a few weeks, his symptoms started to flare up again. This time, no treatment seemed to work despite visits to numerous medical professionals.

At one point, the man became so inebriated that he fell and experienced bleeding in his brain. He was taken to a neurosurgical center where he spontaneously recovered in 10 days, researchers said.

"In this institution, his blood alcohol levels ranged from 50 to 400 mg/dL," the researchers wrote. "Here too, the medical staff refused to believe that he did not drink alcohol despite his persistent denials."

Finally, the man sought help from an online support group and got in touch with the researchers at the Richmond University Medical Center, who said in the study that they believed the antibiotics he took years ago altered his gut microbiome and allowed fungi to grow in his gastrointestinal tract.

The researchers then used antifungal therapies and probiotics to help normalize the bacteria in his gut, a treatment that he has continued. And aside from one relapse that occurred after he binged on pizza and soda without telling the researchers, it seems to be working.

And he can eat pizza again.

"Approximately 1.5 years later, he remains asymptomatic and has resumed his previous lifestyle, including eating a normal diet while still checking his breath alcohol levels sporadically," the authors wrote in the study.

The condition is rarely diagnosed

There have only been a few studies documenting cases of gut fermentation syndrome and the condition is rarely diagnosed, Malik said. In the past, it's even been regarded as a myth.

Gut fermentation syndrome was described in 1912 as "germ carbohydrate fermentation," and was studied in the 1930s and 1940s as a contributing factor to vitamin deficiencies and irritable bowel syndrome. A group of 20 to 30 cases popped up in Japan in the 1970s and the first US cases were reported about 10 years later.

There have been a handful of reported cases in recent years. A 2013 study described a case of a 61-year-old man who for years seemed to be drunk all the time before he was diagnosed with gut fermentation syndrome. In 2015, a woman in upstate New York had a DUI dismissed after presenting evidence that she had the condition.

The authors of the Richmond University Medical Center study recommend that doctors investigate for the condition especially when a patient shows elevated blood alcohol levels despite denying that they consumed alcohol.

Early signs of gut fermentation syndrome can include mood changes, delirium and brain fog, the researchers wrote, even before a patient starts exhibiting symptoms of alcohol inebriation.

The study says more research should be done on the use of probiotics as a treatment for the condition.

"This is a condition that is treatable with dietary modifications, appropriate antifungal therapy, and possibly probiotics," the researchers wrote. "The use of probiotics and faecal microbiota transplantation could be considered for future studies."

The-CNN-Wire
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Kommentarer:

  1. Matteo

    Relevant. Hvor kan jeg finde mere information om dette spørgsmål?

  2. Rudy

    Meget sjovt svar

  3. Steiner

    vidunderligt, det er stykket af værdi



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